A novel family of genes encoding putative pheromone receptors in mammals

@article{Dulac1995ANF,
  title={A novel family of genes encoding putative pheromone receptors in mammals},
  author={Catherine Dulac and Richard Axel},
  journal={Cell},
  year={1995},
  volume={83},
  pages={195-206}
}
In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). Pheromones activate the VNO and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Differential screening of cDNA libraries constructed from single sensory neurons from the rat VNO has led to the isolation of a family of about 30 putative… Expand
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899 Citations
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899 Citations

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Expression of candidate pheromone receptor genes in vomeronasal neurons.
TLDR
The isolation of these receptors from the VNO might permit the analysis of the molecular events which translate the bindings of pheromones into innate stereotypic behaviors and help to elucidate the logic of phersomone perception in mammals. Expand
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
TLDR
A novel multigene family that codes for a diverse array of candidate pheromone receptors (VRs) expressed by the G alpha(o)+ subset is identified, suggesting a distributed mode of sensory coding. Expand
A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution
TLDR
Patterns of receptor gene expression suggest that the VNO is organized into discrete and sexually dimorphic functional units that may permit segregation of pheromone signals leading to specific arrays of behaviors and neuroendocrine responses. Expand
A Novel Family of Candidate Pheromone Receptors in Mammals
TLDR
A novel gene family encoding over one hundred VNO specific receptors, the V3Rs, is identified, likely to represent a new large family of pheromone receptors in mammals. Expand
A New Multigene Family of Putative Pheromone Receptors
TLDR
A new multigene family of G protein-linked receptors (V2Rs) that are specifically expressed in the VNO that are related to the Ca2+-sensing receptor and metabotropic glutamate receptors. Expand
A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna
TLDR
A novel family of seven transmembrane domain proteins, encoded by 100 to 200 genes, that is likely to represent the family of Drosophila odorant receptors are identified and may ultimately afford a system to understand the mechanistic link between odor recognition and behavior. Expand
Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes
TLDR
The behavioural impairment and chemosensory deficit support a role of V1r receptors as pheromone receptors, and the deletion of a ∼600-kilobase genomic region that contains a cluster of 16 intact V1R genes is deleted. Expand
A Map of Pheromone Receptor Activation in the Mammalian Brain
TLDR
Observations indicate that the organization of the vomeronasal sensory afferents is dramatically different from that of the main olfactory system, and these differences have important implications for the logic of Olfactory coding in the vomeenasal organ. Expand
A putative pheromone receptor gene is expressed in two distinct olfactory organs in goats.
TLDR
The results suggest that the goat may detect pheromone molecules through two distinct olfactory organs, and the newly isolated goat receptor genes are members of the V1R gene family. Expand
A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila
TLDR
In situ hybridization and transgene experiments that reveal expression of candidate gustatory receptors in both gustatory and olfactory neurons in adult flies and larvae provide insight into the diversity of chemosensory recognition and an initial view of the representation of gustatory information in the fly brain. Expand
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