A novel extended sequence learning task (ESLeT) for rodents: Validation and the effects of amphetamine, scopolamine and striatal lesions

@article{Dunnett2012ANE,
  title={A novel extended sequence learning task (ESLeT) for rodents: Validation and the effects of amphetamine, scopolamine and striatal lesions},
  author={Stephen B. Dunnett and Anna M. Fuller and Anne Rosser and Simon Philip Brooks},
  journal={Brain Research Bulletin},
  year={2012},
  volume={88},
  pages={237-250}
}
Neurodegenerative diseases of the basal ganglia have been associated with impairments in 'implicit learning', failing to detect repeated sequences embedded in long series of random stimuli. The present study has introduced a novel 5-step sequence learning task (ESLeT) for rats, in which the animals learn to respond to randomly occurring stimuli in a horizontal spatial array, and to chain 5 sequential stimulus-response choices to gain food reward. The rats exhibit improved performance in both… CONTINUE READING