A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer

@article{Tymms1997ANE,
  title={A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer},
  author={Martin Tymms and Annie N Y Ng and Ross S. Thomas and Brian C. Schutte and Jiong Zhou and Helen J. Eyre and Grant R. Sutherland and A. P. Seth and Martin Goldstern Hajime Machida Ivo G. Rosenberg and Takis S. Papas and Christine Debouck and Ismail Kola},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={2449-2462}
}
The ETS family of genes are implicated in cancers such as Ewings sarcoma, acute myeloid leukemia and chronic myelomoncytic leukemia. Further, they have important functions in embryonic development. Hence, identification and characterization of members of this family are important. We identify a novel ETS family member, ELF3, and report its human and murine cDNA sequences. The mouse cDNA has an alternatively spliced transcript with an extra 60 bp inserted. Hence we present the organization of… CONTINUE READING

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Mentioned Connections BETA
ExonsNo subtypeIntrons
This gene consists of 9 exons and 8 introns spanning 4.8 kb .
IntronsNo subtypeExons
This gene consists of 9 exons and 8 introns spanning 4.8 kb .
Intriguingly , the gene is specifically expressed in cell lines of epithelial origin and in organs such as lung , stomach , intestine , kidney that have specialized epithelial cells .
The ETS family of genes are implicated in cancers such as Ewings sarcoma , acute myeloid leukemia and chronic myelomoncytic leukemia .
The ETS family of genes are implicated in cancers such as Ewings sarcoma , acute myeloid leukemia and chronic myelomoncytic leukemia .
The ETS family of genes are implicated in cancers such as Ewings sarcoma , acute myeloid leukemia and chronic myelomoncytic leukemia .
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