A novel endophytic Huperzine A–producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata

@article{Zhu2010ANE,
  title={A novel endophytic Huperzine A–producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata},
  author={D Zhu and Jia-Huai Wang and Q. Zeng and Zunping Zhang and Ri-ming Yan},
  journal={Journal of Applied Microbiology},
  year={2010},
  volume={109}
}
  • D. Zhu, J. Wang, +2 authors R. Yan
  • Published 1 October 2010
  • Biology, Medicine
  • Journal of Applied Microbiology
Aims:  To characterize and identify a novel Huperzine A (HupA)‐producing fungal strain Slf14 isolated from Huperzia serrata (Thunb. ex Murray) Trev. in China. 
Cholinesterase inhibitor (Altenuene) from an endophytic fungus Alternaria alternata: optimization, purification and characterization
The aim of this study was to screen endophytic fungi isolated from Vinca rosea for their potential to produce acetylcholinesterase (AChE) inhibitors.
Identification of a Huperzine A-producing endophytic fungus from Phlegmariurus taxifolius
TLDR
The C17 fungus isolate from the Mexican club moss Phlegmariurus taxifolius, which produced a yield of 3.2 μg/g Hup A in mycelial dry weight, when cultured in potato dextrose broth medium is obtained.
Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A
TLDR
Strain ES026 strain was identified as Colletotrichum gloeosporioides by morphology, polymerase chain reaction with species-specific primers and rDNA internal transcribed spacer sequence, and contributes to the breeding of cultivated strains with high yield of huperzine A.
A novel huperzine A-producing endophytic fungus Fusarium sp. Rsp5.2 isolated from Huperzia serrate
The isolation, identification and characterization of a novel huperzine A (HupA)-producing fungal strain Rsp5.2 isolated from Huperzia serrata (Thunb. ex Murray) Trev. in Vietnam. The fifty-eight
Huperzine A production by Paecilomyces tenuis YS-13, an endophytic fungus isolated from Huperzia serrata
TLDR
This work established a rapid and efficient model for screening HupA-producing endophytic fungal strains from the Chinese folk herb, Huperzia serrata, and reported the first report of P. tenuis as a H upA- producing endophyte isolated from Huperziaceae.
Isolation of endophytic fungi and screening of Huperzine A–producing fungus from Huperzia serrata in Vietnam
TLDR
Endophytic fungi isolated from healthy tissues of H. serrata are identified and a promising candidate and alternative to presently available HupA production techniques for treating AD and preventing further memory decline is found.
Whole-Genome Shotgun Assembly and Analysis of the Genome of Shiraia sp. Strain Slf14, a Novel Endophytic Fungus Producing Huperzine A and Hypocrellin A
ABSTRACT Here, we report the draft genome sequence of Shiraia sp. strain Slf14 (China Center for Type Culture Collection [CCTCC] no. 209294), which is used to produce huperzine A and hypocrellin A.
Research on endophytic fungi for producing huperzine A on a large-scale
TLDR
The progress in research on the methods to increase HupA production is summarized, including fermentation conditions, fungal elicitors, gene expression, and the activation of key enzymes, and new approaches for studies on the regulation of high-value bioactive secondary metabolites are offered.
Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation
TLDR
This study maintained the stability and viability of the HupA-producing endophytic fungus Shiraia sp.
Endophytes in the plant Huperzia serrata: fungal diversity and discovery of a new pentapeptide
TLDR
H. serrata has a significant diversity of endophytic fungi that could be a rich resource for the discovery of new natural products and the potential for discovering novel fungal natural products is investigated.
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References

SHOWING 1-10 OF 48 REFERENCES
Endophytic taxol-producing fungi from bald cypress, Taxodium distichum.
TLDR
In the case of one strain of P. microspora (CP-4), taxol was isolated from culture medium and was shown to be identical to authentic taxol by chromatographic and spectroscopic means.
Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana.
TLDR
Pestalotiopsis microspora was isolated from the inner bark of a small limb of Himalayan yew, and was shown to produce taxol in mycelial culture, and spectroscopic and chromatographic comparisons with authentic taxol were identified.
The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
Huperzine A and B, two new Lycopodium alkaloids isolated from Huperziaserrata (Thunb.) Trev., are shown to possess structures 1 and 3, respectively, on the basis of chemical and spectroscopic data.
Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.
TLDR
Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
Isolation and preliminary identification of the endophytic fungi which produce Hupzine A from four species in Hupziaceae and determination of Huperzine A by HPLC
TLDR
Endophytic fungi producing Hupzine A has been successfully isolated from P. cryptomerianus, and the strains were identified by microscopic features.
Isolation and identification of a new hypocrellin A-producing strain Shiraia sp. SUPER-H168.
A new hypocrellin A-producing strain, Shiraia sp. SUPER-H168, was isolated from tissues of bamboo, Brachystachyum densiflorum. The morphology of this strain was characterized with a light microscope
Molecular diversity of bamboo-associated fungi isolated from Japan.
TLDR
The findings of this study reveal that bamboos are a huge reservoir of microorganisms that should be extensively investigated.
Bioprospecting for Microbial Endophytes and Their Natural Products
TLDR
Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
Huperzine A from Huperzia species--an ethnopharmacolgical review.
TLDR
HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe.
Study on fermentation condition for production of huperzine A from endophytic fungus 2F09P03B of Huperzia serrata
TLDR
The fermentation condition markedly affects the production of huperzine A from the strain 2F09P03B, and since the optimized fermentation condition significantly increases the production, it can be a new medicinal resources of hUPERZine A.
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3
4
5
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