A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima.

@article{Minagawa2004ANE,
  title={A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima.},
  author={Asako Minagawa and Hiroaki Takaku and Masamichi Takagi and Masayuki Nashimoto},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={15688-97}
}
The tRNA 3'-terminal CCA sequence is essential for aminoacylation of the tRNAs and for translation on the ribosome. The tRNAs are transcribed as larger precursor molecules containing 5' and 3' extra sequences. In the tRNAs that do not have the encoded CCA, the 3' extra sequence after the discriminator nucleotide is usually cleaved off by the tRNA 3' processing endoribonuclease (3' tRNase, or RNase Z), and the 3'-terminal CCA residues are added thereto. Here we analyzed Thermotoga maritima 3… CONTINUE READING

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