A novel endogenous inhibitor of phenoloxidase from Musca domestica has a cystine motif commonly found in snail and spider toxins.

@article{Daquinag1999ANE,
  title={A novel endogenous inhibitor of phenoloxidase from Musca domestica has a cystine motif commonly found in snail and spider toxins.},
  author={A C Daquinag and Toshinori Sato and Hirofumi Koda and Toshifumi Takao and Masakazu Fukuda and Yasutsugu Shimonishi and Takashi Tsukamoto},
  journal={Biochemistry},
  year={1999},
  volume={38 7},
  pages={2179-88}
}
Phenoloxidase inhibitor (POI), found in the hemolymph of housefly pupae, is a novel dopa-containing and cystine-rich peptide that competitively inhibits phenoloxidase with a Ki in the nanomolar range. [Tyr32]POI is a potential precursor molecule also found in the hemolymph that may be posttranslationally oxidized to the dopa-containing peptide after creation of a rigid structure. By employing both a solid-phase peptide synthesis system based on a 9-fluorenylmethoxycarbonyl strategy and a… CONTINUE READING

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