A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.

@article{Morse1995ANE,
  title={A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.},
  author={Katherine L. Morse and Donna J Fournier and Xiaoyan Li and Jolanta Grzybowska and Alexandros Makriyannis},
  journal={Life sciences},
  year={1995},
  volume={56 23-24},
  pages={
          1957-62
        }
}
In order to explore the structural requirements for cannabinoid activity we have been involved in the design and synthesis of stereochemically defined high affinity probes for the cannabinoid receptor. This effort has involved the development of irreversible ligands which will allow us to obtain detailed information on the cannabinoid receptor active site(s). The irreversible ligands, which incorporate highly reactive functional groups in a strategic position of the ligand, may form covalent… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…