A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors.

@article{Maison2007ANE,
  title={A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors.},
  author={St{\'e}phane F Maison and Douglas E. Vetter and M Charles Liberman},
  journal={Journal of neurophysiology},
  year={2007},
  volume={97 5},
  pages={3269-78}
}
Outer hair cells in the mammalian cochlea receive a cholinergic efferent innervation that constitutes the effector arm of a sound-evoked negative feedback loop. The well-studied suppressive effects of acetylcholine (ACh) release from efferent terminals are mediated by alpha9/alpha10 ACh receptors and are potently blocked by strychnine. Here, we report a novel, efferent-mediated enhancement of cochlear sound-evoked neural responses and otoacoustic emissions in mice. In controls, a slow… CONTINUE READING
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