A novel effect of amiloride on H+-dependent Na+ transport.


The diuretic amiloride stimulates the rate of decay of a proton gradient in both native ileal brush border membrane vesicles and artificial phospholipid vesicles. The kinetics of the rate of decay of the pH gradient were studied using acridine orange in membrane vesicles equilibrated at pH 5.5 and assayed at pH 8.0. Amiloride stimulated the decay of the… (More)


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