A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse.

@article{Kano2008AND,
  title={A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse.},
  author={Kiyoshi Kano and Caralina Mar{\'i}n de Evsikova and James A. Young and Christopher Wnek and Terry P. Maddatu and Patsy M. Nishina and J{\"u}rgen K Naggert},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 8},
  pages={1866-80}
}
Smallie (slie), a spontaneous, autosomal-recessive mutation causes dwarfing and infertility in mice. The purpose of this study was to determine and characterize the underlying molecular genetic basis for its phenotype. The slie locus was mapped to chromosome 1, and fine-structure mapping narrowed the slie allele within 2 Mb between genetic markers D1Mit36 and Mpz. To pinpoint the underlying mutation quantitative real-time PCR was used to measure the relative expression levels for the genes… CONTINUE READING

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