A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.

@article{Mckie2000AND,
  title={A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.},
  author={Andrew Mckie and Paola Marciani and Andreas Rolfs and Karen Brennan and Kristina Wehr and David Barrow and Silvia Miret and Adrian B Bomford and Timothy J. Peters and Farzin Farzaneh and Matthias A. Hediger and Matthias W. Hentze and Robert J. Simpson},
  journal={Molecular cell},
  year={2000},
  volume={5 2},
  pages={299-309}
}
Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown mechanism. We describe here the isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells. Ireg1 mRNA and protein expression are increased under conditions of… CONTINUE READING
Highly Influential
This paper has highly influenced 48 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS