A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator.

Abstract

All streptococcal genomes encode the alternative sigma factor SigX and 21 SigX-dependent proteins required for genetic transformation, yet no pyogenic streptococci are known to develop competence. Resolving this paradox may depend on understanding the regulation of sigX. We report the identification of a regulatory circuit linked to the sigX genes of mutans… (More)
DOI: 10.1111/j.1365-2958.2010.07361.x

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