A novel dithranol formulation (Micanol): the effects of monotherapy and UVB combination therapy on epidermal differentiation, proliferation and cutaneous inflammation in psoriasis vulgaris.

@article{Vleuten1996AND,
  title={A novel dithranol formulation (Micanol): the effects of monotherapy and UVB combination therapy on epidermal differentiation, proliferation and cutaneous inflammation in psoriasis vulgaris.},
  author={C. V. D. van der Vleuten and M. Gerritsen and E. D. de Jong and M. Elbers and G. D. de Jongh and P. V. D. van de Kerkhof},
  journal={Acta dermato-venereologica},
  year={1996},
  volume={76 5},
  pages={
          387-91
        }
}
Micanol, in which dithranol is micro-encapsulated in crystalline monoglycerides, is easy to wash off and staining and irritation are inconspicuous. These features make it appropriate to use in an out-patient setting. In this study the immunohistochemical effects of this new dithranol formulation were studied and compared with UVB and the combination of these therapies in skin biopsies of 8 patients with psoriasis. Markers for epidermal differentiation, proliferation and cutaneous inflammation… Expand
Dithranol in an Emulsifying Oil Base (Bio-Wash-Oil) for the Treatment of Psoriasis of the Scalp
TLDR
Dithranol in a bio-wash-oil is an effective, well-tolerated and low-priced treatment in psoriasis of the scalp and is significantly better than in groups 2 and 3, as were the overall response and patients’ assessment at the end of treatment. Expand
Standard and innovative therapy of psoriasis.
TLDR
There is no cure for psoriasis, a variety of therapeutic modalities is available to reduce the severity and increase the life quality of the patient, and a risk-benefit ratio must be taken into account. Expand
Standard and innovative therapy of psoriasis.
TLDR
There is no cure for psoriasis, a variety of therapeutic modalities is available to reduce the severity and increase the life quality of the patient, and a risk-benefit ratio must be taken into account. Expand
Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol.
TLDR
The in vitro permeation study using mouse abdominal skin shows significantly enhanced permeation with vesicles as indicated by flux of dithranol from liposomes and niosomes as compared with the cream base. Expand
The epidermis as a target for antipsoriatic treatment; the Nijmegen view
TLDR
In contrast to the in vitro situation, during treatment of psoriatic plaques in vivo a rather consistent pattern is observed for all antipsoriatic treatments with a reduction of involucrin-, transglutaminase-and keratin 16-positive cell layers and an increase in the number of filaggrin- positive cell layers. Expand
COVETIOAL TOPICAL TREATMETS OF PSORIASIS
TLDR
Various topical agents such as tar, dithranol, corticosteroids, salicylic acid, methotrexate, allantoin has been used for treating psoriasis and several reports claim to treat the Psoriasis. Expand
The psoriatic patient and the use of topical antipsoriatics
TLDR
Although studies on the relationship between stress and psoriasis are often at variance, there seems to be a subgroup of patients in whom stress is a precipitating factor and there are still disadvantages of regular treatment. Expand
Ethyl acetate fraction of Radix rubiae inhibits cell growth and promotes terminal differentiation in cultured human keratinocytes.
TLDR
The present experimental findings unequivocally confirmed the keratinocyte terminal differentiation promoting capacity of Radix rubiae, and strongly suggest that Radx rubiae is a promising antipsoriatic agent warranting further clinical development for psoriasis treatment. Expand
Dithranol, Vitamin D 3 -Analoga und 8-Methoxypsoralen
TLDR
Bereits 1877 hat Squire gefunden, dass Goapuder eine Wirkung auf die Psoriasis hat, als wirksame Substanz stellte sich Chrysarobin heraus, und Dithranol ist somit eine der altesten Pharmaka, die in der externen Therapie eingesetzt werden. Expand