A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development

Abstract

Congenital inability to feel pain is very rare but the identification of causative genes has yielded significant insights into pain pathways and also novel targets for pain treatment. We report a novel recessive disorder characterized by congenital insensitivity to pain, inability to feel touch, and cognitive delay. Affected individuals harboured a… (More)
DOI: 10.1093/brain/awv149

7 Figures and Tables

Topics

  • Presentations referencing similar topics