A novel direct spray-from-tissue ionization method for mass spectrometric analysis of human brain tumors.

@article{Kononikhin2015AND,
  title={A novel direct spray-from-tissue ionization method for mass spectrometric analysis of human brain tumors.},
  author={Alexey S. Kononikhin and Evgeny Zhvansky and Vsevolod Shurkhay and Igor A. Popov and Denis Bormotov and Yury Kostyukevich and Sofiia Karchugina and Maria I. Indeykina and Anna E Bugrova and Natalia L. Starodubtseva and A. V. Potapov and Evgeny N. Nikolaev},
  journal={Analytical and bioanalytical chemistry},
  year={2015},
  volume={407 25},
  pages={7797-805}
}
Real-time feedback about dissected tissue during the neurosurgical procedure is strongly requested. A novel direct ionization mass spectrometric method for identifying pathological differences in tissues is proposed. The method is based on simultaneous extraction of tissue lipids and electrospray ionization which allows mass spectrometric data to be… CONTINUE READING