A novel dimeric dipeptide mimetic of the BDNF selectively activates the MAPK-Erk signaling pathway

Abstract

On the basis of the structure of beta-turn of loop 2 of brain-derived neurotrophic factor (BDNF), its new dimeric dipeptide mimetic bis-(N-hexanoyl-L-seryl-L-lysine) hexamethylenediamide (GTS-201) was created. It activated TrkB and Erk, did not activate Akt, and exhibited neuroprotective activity in vitro at concentrations of 10–5–10–8 M. Unlike the mimetics that activate Erk and Akt, GTS-201 did not exhibit antidepressant properties. For the manifestation of the antidepressant activity of BDNF mimetics, the activation of its both major signaling pathways is required.

DOI: 10.1134/S1607672917050027

Cite this paper

@article{Gudasheva2017AND, title={A novel dimeric dipeptide mimetic of the BDNF selectively activates the MAPK-Erk signaling pathway}, author={Tatyana A. Gudasheva and Andrij Tarasiuk and N. M. Sazonova and P. Yu. Povarnina and Tatyana A. Antipova and Sergey B. Seredenin}, journal={Doklady Biochemistry and Biophysics}, year={2017}, volume={476}, pages={291-295} }