A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity.

Abstract

We have synthesized novel phosphonic acid analogues of beta-diketo acids. Interestingly, the phosphonic acid isostere, 2, of our anti-HIV compound, 1, was an inhibitor of only the strand transfer step, in stark contrast to 1. Compound 2 had lower anti-HIV activity than 1, but was more active and less toxic than the phosphonic acid analogue of L-708906… (More)

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@article{Chi2007AND, title={A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity.}, author={Guochen Chi and Vasu Nair and Elena A. Semenova and Yves Pommier}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 5}, pages={1266-9} }