A novel differential expression system for gene modulation in Mycobacteria.

  title={A novel differential expression system for gene modulation in Mycobacteria.},
  author={Xiao-Yong Fan and Hui Ma and Jian Guo and Zhong-ming Li and Zhi-Heng Cheng and Sheng-qi Guo and Guo-Ping Zhao},
  volume={61 1},
Tuberculosis (TB) remains a major global health problem, and successful genetic manipulation of mycobacteria is crucial for developing new approaches to study the mechanism of pathogenesis of Mycobacterium tuberculosis (M.tb) and to combat TB. In this study, a series of M.tb furA gene operator/promoter (pfurA) mutants were generated aiming at optimization of the promoter activities in mycobacterial strains. Measured by the lacZ gene-fusion reporter system, change of the initial codon GTG to the… CONTINUE READING


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