• DOI:10.1016/S0014-5793(01)03085-X
Corpus ID: 24383373

A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer

@article{Zhang2001AND,
  title={A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer},
  author={W. Zhang and Y. Dai and U. Schmitz and T. W. Bruice},
  journal={FEBS Letters},
  year={2001},
  volume={509}
}

W. Zhang, Y. Dai, +1 author T. W. Bruice

Published 2001

Chemistry, Medicine

FEBS Letters

We have investigated DNA binding properties of a dicationic polyamide molecule (GL020924) that has exhibited unique protein displacement and gene regulation activities. Fluorescence, thermal melting and electrospray ionization mass spectrometry experiments showed that the binding stoichiometry of GL020924 is 2:1 to various DNA oligomers with 8–11 contiguous A/T bp. In accordance with those findings, circular dichroism experiments showed GL020924 binds as a partially staggered side‐by‐side dimer… CONTINUE READING

View on Wiley

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed