A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer

@article{Zhang2001AND,
  title={A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer},
  author={W. Zhang and Y. Dai and U. Schmitz and T. W. Bruice},
  journal={FEBS Letters},
  year={2001},
  volume={509}
}
  • W. Zhang, Y. Dai, +1 author T. W. Bruice
  • Published 2001
  • Chemistry, Medicine
  • FEBS Letters
  • We have investigated DNA binding properties of a dicationic polyamide molecule (GL020924) that has exhibited unique protein displacement and gene regulation activities. Fluorescence, thermal melting and electrospray ionization mass spectrometry experiments showed that the binding stoichiometry of GL020924 is 2:1 to various DNA oligomers with 8–11 contiguous A/T bp. In accordance with those findings, circular dichroism experiments showed GL020924 binds as a partially staggered side‐by‐side dimer… CONTINUE READING
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