A novel detection strategy for odorant molecules based on controlled bioengineering of rat olfactory receptor I7.

@article{Hou2007AND,
  title={A novel detection strategy for odorant molecules based on controlled bioengineering of rat olfactory receptor I7.},
  author={Yanxia Hou and Nicole Jaffrezic-Renault and Claude Martelet and Aidong Zhang and Jasmina Minic-Vidic and Tatiana Gorojankina and Marie-Annick Persuy and E. Pajot-Augy and Roland Salesse and Vladimir Akimov and Lino Reggiani and C. Pennetta and Eleonora Alfinito and Oscar J. Ruiz and Gabriel Gomila and Josep Samitier and Abdelhamid Errachid},
  journal={Biosensors & bioelectronics},
  year={2007},
  volume={22 7},
  pages={1550-5}
}
In this study, we report a dose-dependent detection of odorant molecules in solution by rat olfactory receptor I7 (OR I7) in its membrane fraction. The OR I7 is immobilized on a gold electrode by multilayer bioengineering based on a mixed self-assembled monolayer and biotin/avidin system, which allows for a well-controlled immobilization of the bioreceptor within its lipid environment. The odorant detection is electronically performed in a quantitative manner by electrochemical impedance… CONTINUE READING

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