A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

@inproceedings{Gehmlich2011AND,
  title={A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions},
  author={Katja Gehmlich and Pier Lambiase and Angeliki Asimaki and Edward J. Ciaccio and Elisabeth Ehler and Petros Syrris and Jeffrey E. Saffitz and William J. McKenna},
  booktitle={Heart rhythm},
  year={2011}
}
BACKGROUND Cellular adhesion mediated by cardiac desmosomes is a prerequisite for proper electric propagation mediated by gap junctions in the myocardium. However, the molecular principles underlying this interdependence are not fully understood. OBJECTIVE The purpose of this study was to determine potential causes of right ventricular conduction abnormalities in a patient with borderline diagnosis of arrhythmogenic right ventricular cardiomyopathy. METHODS To assess molecular changes, the… CONTINUE READING

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