A novel deletion of the MEN1 gene in a large family of multiple endocrine neoplasia type 1 (MEN1) with aggressive phenotype.

@article{Raef2011AND,
  title={A novel deletion of the MEN1 gene in a large family of multiple endocrine neoplasia type 1 (MEN1) with aggressive phenotype.},
  author={Hussein Raef and Minjing Zou and Essa Y. Baitei and Roua A. Al-Rijjal and Namik Kaya and Mohamed H. Al-Hamed and Dorota Monies and Nada Abudheim and Hindi Al-Hindi and Mohammed H. Alghamdi and Brian F. Meyer and Yufei Shi},
  journal={Clinical endocrinology},
  year={2011},
  volume={75 6},
  pages={
          791-800
        }
}
CONTEXT The MEN1 syndrome is associated with parathyroid, pancreatic and pituitary tumours and is caused by mutations in the MEN1 gene. In general, there is no genotype-phenotype correlation. OBJECTIVES To characterize a large family with MEN1 with aggressive tumour behaviour: malignant pancreatic endocrine tumours were present in five affected subjects and were the presenting features in three subjects. DESIGN The coding region of MEN1 was sequenced. Gene copy number analysis was performed… CONTINUE READING

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