A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth

Background:Antiangiogenic therapies have been proven effective in cancer treatment. Fibroblast growth factor-2 (FGF-2) has been functionally implicated in tumour angiogenesis and is an important target of antiangiogenic therapies. The aim of this work was to develop a novel FGF-2 inhibitor for cancer therapy.Methods:Eleven fusion proteins were developed by… CONTINUE READING