A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions

@inproceedings{Moseley2011AND,
  title={A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions},
  author={Hunter N. B. Moseley and Andrew N. Lane and Alex C Belshoff and Richard M. Higashi and Teresa W.-M. Fan},
  booktitle={BMC Biology},
  year={2011}
}
BackgroundStable isotope tracing is a powerful technique for following the fate of individual atoms through metabolic pathways. Measuring isotopic enrichment in metabolites provides quantitative insights into the biosynthetic network and enables flux analysis as a function of external perturbations. NMR and mass spectrometry are the techniques of choice for global profiling of stable isotope labeling patterns in cellular metabolites. However, meaningful biochemical interpretation of the… CONTINUE READING

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