A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.

@article{Williams2003ANC,
  title={A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.},
  author={Russell B Williams and Jeannine M Hoch and Thomas E. Glass and Richard J. Evans and Sylvain G. Razafimandimbison and Jan H. Wisse and David G I Kingston},
  journal={Planta medica},
  year={2003},
  volume={69 9},
  pages={
          864-6
        }
}
Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC (50) values of 6.8 and 8.0 microg/mL, respectively. 
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

A Method of Effectively Improved α-Mangostin Bioavailability

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2015

Similar Papers

Loading similar papers…