A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.

@article{Williams2003ANC,
  title={A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.},
  author={Russell B. Williams and Jeannine M Hoch and Thomas E Glass and Randy Evans and J. George Miller and Jan H Wisse and David G I Kingston},
  journal={Planta medica},
  year={2003},
  volume={69 9},
  pages={864-6}
}
Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC (50) values of 6.8 and 8.0 microg/mL, respectively. 

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