A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.

@article{Schlosser2007ANC,
  title={A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.},
  author={Eva Schlosser and Carolina Otero and Christine Wuensch and Benedikt M. Kessler and Mariola J Edelmann and Ren{\'e} Brunisholz and Ingo Drexler and Daniel F Legler and Marcus Groettrup},
  journal={EMBO reports},
  year={2007},
  volume={8 10},
  pages={945-51}
}
Proteins bearing an endoplasmic reticulum (ER) leader are inserted into the ER followed by cleavage of the signal peptide. Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. Here, we show that an HLA-A(*)0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. The resulting cleavage products fail to bind to HLA-A(*)0201 and are… CONTINUE READING