A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor

Abstract

The class II major histocompatibility complex (MHC) molecules function in the presentation of processed peptides to helper T cells. As most mammalian cells can endocytose and process foreign antigen, the critical determinant of an antigen-presenting cell is its ability to express class II MHC molecules. Expression of these molecules is usually restricted to… (More)

Topics

6 Figures and Tables

Cite this paper

@article{Song1994ANC, title={A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor}, author={Z. Song and S. Krishna and Dimitris Thanos and Jack Leonard Strominger and Santa Jeremy Ono}, journal={The Journal of Experimental Medicine}, year={1994}, volume={180}, pages={1763 - 1774} }