A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.

@article{Labunskyy2005ANC,
  title={A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.},
  author={Vyacheslav M Labunskyy and Andrew D. Ferguson and Dmitri E. Fomenko and Yogarany Chelliah and Dolph Lee Hatfield and Vadim N. Gladyshev},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 45},
  pages={37839-45}
}
Selenium is an essential trace element with potent cancer prevention activity in mammals. The 15-kDa selenoprotein (Sep15) has been implicated in the chemopreventive effect of dietary selenium. Although the precise function of Sep15 remains elusive, Sep15 co-purifies with UDP-glucose:glycoprotein glucosyltransferase (GT), an essential regulator of quality control mechanisms within the endoplasmic reticulum. Recent studies identified two GT and two Sep15 homologues in mammals. We characterize… CONTINUE READING

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