A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells.

@article{Obara2007ANC,
  title={A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells.},
  author={Yutaro Obara and Tomohiro Hoshino and Maria Carla Marcotullio and Rita Pagiotti and Norimichi Nakahata},
  journal={Life sciences},
  year={2007},
  volume={80 18},
  pages={1669-77}
}
We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059, but not by the protein kinase C… CONTINUE READING