A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel.

@article{Pruetting2011ANC,
  title={A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel.},
  author={Sylvia Pruetting and Stephan Grissmer},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={20031-42}
}
Voltage-gated potassium channels are proteins composed of four subunits consisting of six membrane-spanning segments S1-S6, with S4 as the voltage sensor. The region between S5 and S6 forms the potassium-selective ion-conducting central α-pore. Recent studies showed that mutations in the voltage sensor of the Shaker channel could disclose another ion permeation pathway through the voltage-sensing domain (S1-S4) of the channel, the ω-pore. In our studies we used the voltage-gated hKv1.3 channel… CONTINUE READING
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