A novel controlled release PLGA microspheres for the antisense oligonucleotide

SUMMARY In this article,A novel controlled release formulation for the antisense oligonucleotide was developed based on the Biodegradable poly D, L-lactide-co-glycolide (PLGA) and Hydrophobically modified olyethylenimine(PEI-LA). INTRODUCTION Antisense oligonucleotides (ASO) are able to inhibit expression of specific genes by interfering with transcription… (More)