A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones.

  title={A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones.},
  author={Marzia Malcangio and Stephen J. Getting and John Grist and Joanna R Cunningham and Elizabeth J. Bradbury and Peter Charbel Issa and Isobel J Lever and Sophie Pezet and Mauro Perretti},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={16 7},
Small-diameter sensory neurones found in the rat dorsal root ganglia (DRG) include cells sensitive to glial cell line-derived neurotrophic factor (GDNF), which express the inhibitory peptide somatostatin (SOM). Here we addressed the functional relationship between GDNF and sensory neurone-derived SOM. Topical application of GDNF through the rat isolated dorsal horn of the spinal cord promoted activity-induced release of SOM from central terminals of sensory neurones. Once released by sensory… CONTINUE READING
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