A novel component of the axonal cortical cytoskeleton, A60, defined by a monoclonal antibody.

A Mr 60,000 protein of the axonal cortical cytoplasm, which is recognized by a novel monoclonal antibody, is described. The antibody, DR1, was produced by immunizing mice with a soluble extract of bovine brain membranes that is enriched in known membrane cytoskeletal proteins. DR1 recognizes a Mr 60,000 protein in this extract. Immunofluorescence and… CONTINUE READING