A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer.

@article{Locke2009ANC,
  title={A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer.},
  author={Jennifer Ann Locke and Ladan Fazli and Hans H. Adomat and Jil Smyl and Kristin Weins and Amy Anne Lubik and Dale Buck Hales and Colleen C. Nelson and Martin E. Gleave and Emma S. Tomlinson Guns},
  journal={The Prostate},
  year={2009},
  volume={69 9},
  pages={928-37}
}
BACKGROUND CYP17A1 is currently a target for total androgen blockade in advanced prostate cancer (CaP) patients. After castration, or removal of testicular androgens, CYP17A1 can act as a rate-limiting enzyme in androgen synthesis from cholesterol or other adrenal precursors within the tumor microenvironment ultimately contributing to disease progression… CONTINUE READING