A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro.

@article{Wei2015ANC,
  title={A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro.},
  author={Y. -J. Wei and Shuai Xu and Feng Wang and Aifeng Zou and Shuang Zhang and Yan Xiong and Shilei Cao and Qizhi Zhang and Yajie Wang and Xinguo Jiang},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 1},
  pages={165-77}
}
Lapatinib (LPT) could sensitize human epidermal growth factor receptor-2 (HER-2) positive breast cancer to paclitaxel (PTX) and induce synergetic action with PTX in preclinical test and phase II/III trial. In this study, LPT-conjugated poly (ethylene glycol) (PEG) and poly (lactic acid) (PLA) (LPT-PEG-PLA) was first synthesized and confirmed with ¹H Nuclear… CONTINUE READING