A novel cofactor for p300 that regulates the p53 response.

  title={A novel cofactor for p300 that regulates the p53 response.},
  author={Noriko Shikama and Connie W.C. Lee and Stefan France and Laurent Delavaine and Jon J Lyon and Marija Krstic-Demonacos and Nicholas B. La Thangue},
  journal={Molecular cell},
  volume={4 3},
The ability of p53 to function as a transcription factor is instrumental in facilitating the response to cellular stress, and p300/CBP proteins, which act as coactivators for diverse transcription factors, participate in regulating p53 activity. We report a novel cofactor for p300 that facilitates the p53 response by augmenting p53-dependent transcription and apoptosis. JMY and p300 associate in physiological conditions, and, during the cellular stress response, the p300/JMY complex is… CONTINUE READING

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