A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.

@article{Abe1998ANC,
  title={A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.},
  author={Yoshihisa Abe and Hiroshi Kayakiri and Shigeki Satoh and Takayuki Inoue and Yuki Sawada and Noriaki Inamura and Masayuki Asano and Ichiro Aramori and Chie Hatori and H Sawai and Teruo Oku and Hirokazu Tanaka},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 21},
  pages={4062-79}
}
Recently we reported on overcoming the species difference of our first orally active non-peptide bradykinin (BK) B2 receptor antagonists, incorporating an 8-[[3-(N-acylglycyl-N-methylamino)-2, 6-dichlorobenzyl]oxy]-3-halo-2-methylimidazo[1,2-a]pyridine skeleton, leading to identification of the first clinical candidate 4a (FR167344). With this potent new… CONTINUE READING