A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.

@article{Cox1998ANC,
  title={A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.},
  author={Daniel N. Cox and Antonia Chao and Joshua L. Baker and Lindsay Chang and Dan Qiao and Haifan Lin},
  journal={Genes & development},
  year={1998},
  volume={12 23},
  pages={
          3715-27
        }
}
Germ-line stem cells (GSCs) serve as the source for gametogenesis in diverse organisms. We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter GSC but is not essential for the further differentiation of the committed daughter cell. Genetic mosaic and RNA in situ analyses suggest that piwi expression in adjacent somatic cells regulates GSC division. piwi encodes a highly basic novel protein, well… CONTINUE READING
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