A novel class of cell surface glycolipids of mammalian cells. Free glycosyl phosphatidylinositols.

@article{Singh1996ANC,
  title={A novel class of cell surface glycolipids of mammalian cells. Free glycosyl phosphatidylinositols.},
  author={Neena Singh and Li-na Liang and Mark L. Tykocinski and Alan Michael Tartakoff},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 22},
  pages={12879-84}
}
Glycosyl phosphatidylinositol (GPI) lipids function as anchors of membrane proteins, and free GPI units serve as intermediates along the path of GPI-anchor biosynthesis. By using in vivo cell surface biotinylation, we show that free GPIs: 1) can exit the rough endoplasmic reticulum and are present on the surface of a murine EL-4 T-lymphoma and a human carcinoma cell (HeLa), 2) arrive at the cell surface in a time and temperature-dependent fashion, and 3) are built on a base-labile glycerol… CONTINUE READING
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