A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists – in vitro characterization

@article{Gilling2007ANC,
  title={A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists – in vitro characterization},
  author={K. Gilling and C. Jatzke and C. Wollenburg and M. Vanejevs and V. Kauss and A. Jirgensons and C. Parsons},
  journal={Journal of Neural Transmission},
  year={2007},
  volume={114},
  pages={1529-1537}
}
SummaryThe fact that potent NMDA receptor channel blockers produce phencyclidine-like psychotropic symptoms in man and rodents implies that uncompetitive antagonism of NMDA receptors may not be a promising therapeutic approach. However, recent data indicate that agents with moderate affinity such as memantine and neramexane (MRZ 2/579) are useful therapeutics due to their strong voltage-dependency and rapid unblocking kinetics. Merz has developed a series of novel uncompetitive NMDA receptor… Expand
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