A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.

@article{Palmer1989ANC,
  title={A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.},
  author={Richard M J Palmer and Salvador Moncada},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={158 1},
  pages={348-52}
}
An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.