A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA.

@article{Lo2001ANC,
  title={A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA.},
  author={Anthony Wing-Ip Lo and Dianna J Magliano and Mandy Sibson and Paul Kalitsis and Jeffrey M Craig and K. H. Choo},
  journal={Genome research},
  year={2001},
  volume={11 3},
  pages={448-57}
}
Centromere protein A (CENP-A) is an essential histone H3-related protein that constitutes the specialized chromatin of an active centromere. It has been suggested that this protein plays a key role in the epigenetic marking and transformation of noncentromeric genomic DNA into functional neocentromeres. Neocentromeres have been identified on more than two-thirds of the human chromosomes, presumably involving different noncentromeric DNA sequences, but it is unclear whether some generalized… CONTINUE READING