A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.

@article{Reid2004ANC,
  title={A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.},
  author={Patrick C. Reid and Naomi Sakashita and Shigeki Sugii and Yoshiko Ohno-Iwashita and Yukiko Shimada and William F. Hickey and T. Y. P. Chang},
  journal={Journal of lipid research},
  year={2004},
  volume={45 3},
  pages={582-91}
}
Niemann-Pick type C (NPC) is a neurodegenerative disorder characterized by progressive accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and visceral organs. In the NPC1 mouse model, neurodegeneration and neuronal cell loss occur before postnatal day 21. Whether neuronal cholesterol accumulation occurs in vivo before the first signs of neuronal cell loss has not been demonstrated. In this report, we used the NPC1 mouse model and employed a novel… CONTINUE READING

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Neurodegeneration in Niemann-Pick type C disease mice

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