A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties.

@article{Parthsarathy2016ANC,
  title={A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties.},
  author={Vadivel Parthsarathy and Nigel Irwin and Annie Hasib and Christine M A Martin and Stephen McClean and Vikas K. Bhat and Ming Ng and Peter Raymond Flatt and Victor A Gault},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1860 4},
  pages={757-64}
}
BACKGROUND Xenin-25 is a K-cell derived gut peptide with insulin-releasing activity which is rapidly degraded following release into the circulation. We hypothesized that substitution of all naturally-occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy. METHODS Peptide stability was assessed using murine plasma, in vitro insulin-releasing actions evaluated in BRIN-BD11 cells and acute glucose-lowering and insulin-releasing actions… CONTINUE READING

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We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
ArginineNo subtypeLysine
We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
LysineNo subtypeArginine
We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
GlutamineNo subtypeLysine
We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
LysineNo subtypeGlutamine
We hypothesized that substitution of all naturally - occurring Lys and Arg residues with Gln would lead to prolonged enzyme resistance and enhanced biological efficacy .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta - to - alpha cell ratio in xenin-25(gln)-treated mice .
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