A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting.

@article{Hara2007ANC,
  title={A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting.},
  author={Yoshiaki Hara and Naoko Funeshima-Fuji and Masayuki A. Fujino and Kazuhiro Tokunaka and Fuminori Abe and Yoshinobu Sato and Katsuyoshi Hatakeyama and Shiro Takahara and Taichi Ezaki and Hiromitsu Kimura and Xiao-kang Li},
  journal={Transplantation},
  year={2007},
  volume={84 3},
  pages={407-14}
}
BACKGROUND There is great interest in the recently developed immunosuppressant NK026680, which is a derivative of triazolopyrimidine. Its unique chemical structure and action mechanism are completely different from those of conventional immunosuppressants. METHODS The present study was designed to investigate the effects of NK026680 on rat bone-marrow-derived dendritic cell (BMDC) differentiation and maturation in an in vitro culture system and its applicability in liver transplantation… CONTINUE READING