A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway.

@article{Landais2009ANC,
  title={A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway.},
  author={Igor Landais and Alexandra Sobeck and Stacie Stone and A Lachapelle and Maureen Elizabeth Hoatlin},
  journal={International journal of cancer},
  year={2009},
  volume={124 4},
  pages={783-92}
}
The Fanconi Anemia (FA) DNA damage response pathway is involved in the processing of DNA interstrand crosslinks (ICLs). As such, inhibition of the FA pathway could chemosensitize FA-competent tumor cells to commonly used ICL agents like cisplatin. Moreover, suppression of the FA pathway is synthetic lethal with deficiencies in several other DNA repair pathways, suggesting that FA pathway inhibitors could be used in targeted therapies against specific tumors. To identify such inhibitors, we… CONTINUE READING