A novel cell adhesion region in tropoelastin mediates attachment to integrin αVβ5.

@article{Lee2014ANC,
  title={A novel cell adhesion region in tropoelastin mediates attachment to integrin αVβ5.},
  author={Pearl Lee and Daniel V. Bax and Marcela M M Bilek and Anthony S Weiss},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 3},
  pages={1467-77}
}
Tropoelastin protein monomers assemble to form elastin. Cellular integrin αVβ3 binds RKRK at the C-terminal tail of tropoelastin. We probed cell interactions with tropoelastin by deleting the RKRK sequence to identify other cell-binding interactions within tropoelastin. We found a novel human dermal fibroblast attachment and spreading site on tropoelastin that is located centrally in the molecule. Inhibition studies demonstrated that this cell adhesion was not mediated by either elastin-binding… CONTINUE READING