A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.

@article{Pi2004ANC,
  title={A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.},
  author={Min Pi and Leigh Quarles},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2004},
  volume={19 5},
  pages={
          862-9
        }
}
UNLABELLED Defining the molecular target for strontium in osteoblasts is important for understanding the anabolic effects of this cation on bone. The current studies demonstrate that a G-protein-mediated response to strontium persists in osteoblasts that lack CASR, suggesting a predominant role for a novel cation-sensing receptor in mediating the osseous response to strontium. INTRODUCTION Strontium has anabolic effects on bone and is currently being developed for the treatment of… CONTINUE READING

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