A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP, and endothelium-dependent activities.

@article{Lo2003ANC,
  title={A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP, and endothelium-dependent activities.},
  author={Y C Lo and Hui-Chuan Hsiao and Deng-chyang Wu and Rong-Jyh Lin and Jhy-Chong Liang and J Yeh and I J Chen},
  journal={Journal of cardiovascular pharmacology},
  year={2003},
  volume={42 4},
  pages={511-20}
}
The vasorelaxant effects of N-[4-O-[2-methoxy, phenoxyethylaminobutyl]-3-methoxy benzyl]-nonamide (VOA), a novel capsaicin derivative, and associated releasing activities of nitric oxide (NO) and calcitonin gene-related peptide (CGRP) were investigated in this study. Systemic administration of VOA decreased blood pressure and heart rate in a dose-dependent manner in both normotensive as well as spontaneously hypertensive rats. Nw-nitro-L-arginine methyl ester (L-NAME), glibenclamide, and… CONTINUE READING